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Review of the biotechnologies and tests used for precancerous cervical lesions diagnosis Ruxandra Viorica Stanculescu, Elvira Bratila, Vasilica Bausic, Teodora Camelia Vladescu, Florina Vasilescu, Alexandra Bausic, Costin Berceanu This paper draws on the author s extensive experience in the clinical research focused on the implementation of the new biotechnologies able to identify precancerous cervical lesions and is intended to be a systematic approach to new achievements.
The goal of this review is to provide updated information concerning the significance of each herbal slimming gc used in clinical medicine to screen women for cervical cancer or to allow a pertinent discrimination between spontaneous remission lesions and progressive lesions.
The data is arranged according to the most widely used biotechnologies and the worldwide recommendations of specialized guidelines. Angiogenesis herbal slimming gc arteriogenesis Anna Rizzi, Vincenzo Benagiano, Domenico Ribatti In the vascular system, angiogenesis and arteriogenesis play a unique yet equally important role in both health and disease.
Angiogenesis, the formation of new blood vessels from a preexisting vascular bed, occurs naturally during wound healing, the female menstrual cycle and pregnancy. It plays a critical role in tissue growth and repair, and is a highly controlled process that is dependent on an intricate balance of both pro-angiogenic to stimulate and anti-angiogenic to negatively regulate the phenomenon factors.
Otherwise, the term arteriogenesis refers to anatomic transformation of preexisting arterioles with increasing lumen area and wall thickness, due to a thick herbal slimming gc layer herbal slimming gc purchasing of visco-elastic and vasomotor capacities.
Arteriogenesis differs from angiogenesis in several aspects, the most important being the dependence of angiogenesis on hypoxia and the dependence of arteriogenesis on inflammation.
The expression of growth factors and the cooperation of surrounding and infiltrating cells seem to be essential in orchestrating the complex processes during arteriogenesis. Triple positive breast cancer - a novel category? Breast cancer has been divided in subtypes depending on the presence of hormone receptors HRs for estrogen and progesterone and human epidermal growth factor receptor 2 HER2 gene amplification. We aim to review current evidence on this subtype of BC, from the molecular mechanisms regulating its behavior to the current standard treatment outcome in order to establish whether it herbal slimming gc as a new distinct subtype of BC.
Its biology is dominated by the crosstalks between HR pathway and HER2 pathway, which might be responsible for the development of rapid resistance to treatment, because of estrogen receptor up-regulation and alternate regulatory pathways activation when anti-HER2 agents are used.
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However, most of the clinical evidence is provided by retrospective trials with multiple potential biases. Autophagy is present at a basal level in all mammals and is regulated by some conditions, such as oxidative stress, starvation or hypoxia.
In aged tissues, increased but also decreased expression of autophagy-specific proteins, Beclin 1, LC3, Atg5 and Atg7 has been reported. Likewise, it could be shown that the lifespan of yeast, nematodes and flies is prolonged by pharmacologically stimulated autophagy using exogenous administered spermidine.
Exploring the Urtica dioica Leaves Hemostatic and Wound-Healing Potential.
Autophagy is potentially implicated in acute lung injury and sepsis, two main causes of morbidity and mortality worldwide. Finally, a quite recent study supports the hypothesis that autophagy might be useful in vascular disease prevention by stimulating cholesterol efflux, which leads to inhibition of necrotic core formation and lipid accumulation. However, cases of regression have been reported. Recent reviews cover only certain aspects of this disease; therefore, this paper s aim is to cover all the relevant aspects for medical practice, such as clinical, histological and therapeutic details.
BD may affect all regions of the skin and mucosa, but in accordance with the region and etiologic factor, it may embrace different clinical forms, some of them very similar with other skin lesions. Dermoscopy may prove useful for establishing a clinical diagnosis.
Several patterns have been encountered and may help distinguishing from other diseases. When in doubt, puncture biopsy or complete excision may be performed in order to obtain histological data that could define BD.
Different morphological aspects of the involved components are described in herbal slimming gc to reduce the risk of misdiagnose. In order for the approach to be complete, relevant information about treatment herbal slimming gc been presented, underlining the pros and herbal slimming gc of each available therapy. A systematic review of the possible carcinogenic role of the aristolochic acid Tivadar Bara Jr.
AA is also shown to be involved in the genesis of the upper urinary tract urothelial carcinoma UTUC and some other cancers, but its tumorigenic role is far to be understood. We performed a systematic literature review regarding the involvement of AA in malignant processes and molecular pathways of carcinogenesis.
ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY
Twenty representative papers were selected for this review. These papers reveal that AA exposure increases the risk for UTUC, renal cell carcinoma, hepatocellular carcinoma, gastric and small intestine herbal slimming gc. The role of AA in lymphomagenesis is also proposed. For further understanding of AA s role in tumorigenesis, the exploration of the AA s molecular signature is necessary.
The ultraviolet influence upon soft eye tissues Sanda Jurja, Malina Coman, Mihaela-Cezarina Hincu The climate changes, which occurred herbal slimming gc the last decades, put all living species in front of new challenges.
Human biology is no exception to it, all tissues have to face new effects, with unpredictable consequences. Many cancers, mainly affecting the skin, but also many of the eye various structures diseases, have ultraviolet radiation as recognized causative agent. The aim of our work is to highlight the changes that can occur after exposure to ultraviolet radiations of soft tissues, including eye structures, by reviewing data from the scientific literature regarding the matter.
Responsible for severe diseases, including cancer, ultraviolet negative effects on various soft tissues can be limited by better comprehension. Their knowledge can contribute to improving public health, by finding new preventive methods, which might represent the foundation of effective public health programs.
Role of genetic polymorphism in nutritional supplementation therapy in personalized medicine Nicolae Ovidiu Penes, Bernard Weber, Silviu Dumitru Paun Genetic-guided nutritional supplementation therapy in personalized medicine is the type of treatment that prevents and acts against errors during the copying process of a cell s deoxyribonucleic acid DNAmistakes that lead to diversification in the DNA sequence at certain locations, herbal slimming gc herbal slimming gc nucleotide polymorphisms SNPs.
Positive results are quickly achieved using one of the four types of therapy. These types are: personalized, when individual human genetic variations drive individual treatment, preventive, with a tailored healthcare strategy and therapeutic preventive drugs and vaccines, participatory, when empowered patients make informed choices and take responsibility of their own health and predictive, using a herbal slimming gc approach to health and medicine.
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- Ричард пожал плечами и покачал головой.
- Но мы, октопауки, в первую очередь ценим информацию, этому нас научили Предтечи.
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Three-dimensional organ scanning reveals brain edema reduction in a rat model of stroke treated with an aquaporin 4 inhibitor Elena Silvia Popescu, Ionica Pirici, Raluca Niculina Ciurea, Tudor-Adrian Balseanu, Bogdan Catalin, Claudiu Margaritescu, Laurentiu Mogoanta, Sorin Hostiuc, Daniel Pirici Stroke is one of the most important cause of death and disability, especially when considering the increasing life expectancy worldwide, with ischemic stroke being much more common than hemorrhages.
In the physiopathological chain of ischemic stroke, brain edema is one first element that if attended to might reduce tissue necrosis, penumbra, and increase functional recovery. Aquaporin 4 AQP4 has been found to be the most important water channel in the brain, and its inhibition before inducing focal herbal slimming gc in an animal model of stroke proved to alleviate the pathology and improve clinical recovery.
In this study, we have treated a rat model of ischemic stroke with the AQP4 inhibitor TGN after inducing the lesion, and performed for the first time a direct histopathological evaluation of the brain and infarct s volume.
Besides utilizing immunohistochemistry targeting the growth-associated protein Herbal slimming gc in order to delineate the infarct regions, we have used the Cavalieri s principle of tissue volume measurements starting form seriate sections, and for the first time in neuropathology, we have utilized a high-resolution object scanner to assess global brain volume changes. Our results showed that TGN clearly reduces infarct volume in TGN treated animals compared to untreated animals, as well as the volume of the brain hemispheres.
Although reduced, the effect was also present in the contralateral hemisphere. Given these data, herbal slimming gc more in-depth characterization of the histopathological and molecular changes induced by AQP-4 are needed for considering it as a bona fide treatment option.
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Prenatal glucocorticoid administration persistently increased the immunohistochemical expression of type-1 metabotropic glutamate receptor and Purkinje cell dendritic growth in the cerebellar cortex of the rat Rodrigo Pascual, Odra Santander, Isabel Cuevas, Martina Valencia Several studies have indicated that abnormal prenatal changes in the circulating glucocorticoids GCsinduced by either maternal stress or exogenous GC administration, significantly alter the development of Purkinje cells PCs.
Among the suggested herbal slimming gc that could mediate this GC-dependent PC susceptibility are changes in the expression of type-1 metabotropic glutamate receptors mGluR1. In the current study, we analyzed whether a single course of prenatally administered betamethasone phosphate BET in pregnant rats increased the immunohistochemical expression of mGluR1 in PCs and decreased PC dendritic growth.
The data obtained showed that in utero BET exposure resulted in a significant immunohistochemical overexpression of mGluR1 and a significant reduction in Purkinje herbal slimming gc dendritic outgrowth during postnatal life. Large variability of the activity and chronicity herbal slimming gc within and between histological classes of lupus nephritis Tudor Azoicai, Ioana Madalina Belibou, Ludmila Lozneanu, Simona Eliza Giusca, Elena Cojocaru, Irina-Draga Caruntu Systemic lupus erythematosus SLE is characterized by a multifaceted pathogenesis and a heterogeneous clinical expression.
The present study aimed to reevaluate a series of cases diagnosed as LN, focusing on the histological features in correlation with the level of activity and chronicity. The study group comprised 46 patients.
The specimens obtained through percutaneous needle biopsies were processed for light microscopy and herbal slimming gc exams. In 39 out of the total of 46 The differences in diagnosis were present in seven cases, initially considered as pure membranous glomerulonephritis - class V. The values of indexes indicated a great variability of LN within the same class.
The interobserver agreement for the scoring of activity and chronicity indexes was 0. Our study emphasizes the complex lesion character, which requires an individual and accurate identification, followed by integration in the classification algorithm used to define the classes and subclasses of LN diagnosis. The degree of activity and chronicity in SLE must be refined through a much more precise correspondence between the score value and the limitation or extension of corpuscular and interstitial lesions.
Rapid on-site examination ROSE is a rapid, real-time examination method.
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The aim of our study is to evaluate the impact of ROSE on adequate specimen sampling, rapid results and high diagnostic rate. We evaluated the diagnostic capacity of ROSE for malignant tumors, by considering the histopathological examination as the diagnostic gold standard.
In our retrospective and descriptive study, we analyze the data of EBUS-TBNA examinations with ROSE and histopathological exam, performed for diagnostic purposes for hilar and mediastinal adenopathies of unknown origin.
The age of the patients varied from 21 to 80 years, with an average age of There were 98 male patients, representing The sensitivity of the ROSE is This brings herbal slimming gc valuable contribution to herbal slimming gc improvement of lung cancer diagnostic.
The present paper aimed to define the profile of SCC of the lip with major risk factors.
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The study included 20 selected cases diagnosed with lower lip SCC, using a panel of antibodies which addressed cell proliferation Ki67perturbation of the cell cycle p53angiogenesis VEGF - vascular endothelial growth factorfactors related to tumor cell interaction with the extracellular matrix CD Ki67 immunoexpression was identified in all the cases. We found significantly higher mean values of Ki67 PI in pT3 lesion, compared with pT2 and pT lesions, and with no statistically significant differences in lip SCC with associated lymph node metastasis pN1compared to those with no lymph node metastasis pN0.
Immunohistochemical investigations in lip SCC, regarding the expression of p53, Ki67, CD44 and VEGF, revealed results that suggest their ability to assess the prognosis and progression of tumor evolution. Optical coherence tomography applications in tooth wear diagnosis Veronica Mercut, Sanda Mihaela Popescu, Monica Scrieciu, Marina Olimpia Amarascu, Mihaela Vatu, Oana Andreea Diaconu, Eugen Osiac, Stefan Mugurel Ghelase Dental wear represents an irreversible loss of dental hard tissue under the action of physical, chemical and mechanical factors, excluding dental caries and acute trauma.
Four clinical forms of dental wear are described: erosion, attrition, abfraction, and abrasion. Most experts agree that in each clinical avort spontan pierde in greutate multiple etiological factors are involved, one being predominant. Optical coherence tomography OCT is a non-invasive optical method characterized by a herbal slimming gc resolution.
The applications of this type of investigation are multiple in the medical field in recent years, and OCT is gaining a growing importance in dentistry. The herbal slimming gc pointed out through OCT imaging for the erosive tooth wear lesion the existence of chemical aggression, with strong demineralization of enamel and dentin.
For attrition lesion, OCT images showed the contribution of excessive force and friction movements specific to bruxism.
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In abfraction, OCT image revealed the importance of the mechanic factor in producing this form of tooth wear and abrasion damage studied may be considered physiological, according to patient age. OCT examination may reveal existing lesions in hard dental tissues for each clinical form and could bring evidence on the mechanisms involved.
Steatosis may be an important cofactor in both accelerating fibrosis and increasing liver necroinflammatory activity in chronic hepatitis C.